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NIMBUS Select, powered by Ranger® Technology

The NIMBUS Select is a large-scale automated electrophoresis and size selection instrument. Powered by Ranger® Technology, the NIMBUS Select is ideal for high throughput laboratories.

Yourgene Health | Our Products | Instruments | NIMBUS Select

The NIMBUS Select, powered by Ranger® Technology, is a high through-put workstation which enables automated DNA electrophoresis for either size selection or fragment length analysis.

It is ideal for high-throughput laboratories for use in next generation sequencing applications including: cloning, gene synthesis and large fragment analysis/quality control. The NIMBUS Select can also be used in NIPT and oncology applications.

The NIMBUS Select automates the entire process from mixing the samples with loading buffer, loading into their gel cassettes, continuously monitoring and controlling the electrophoretic process, to automated extraction of the size selected DNA into clean labware, ready for downstream processing.

This innovative solution enables accurate, high yield recovery of up to 96 DNA samples in two hours (Size Selection). The automated tracking of the entire process produces both electropherograms of the input sample and artificial traces of the output profile. The flexible software enables additional samples to be loaded after a run has commenced and the output data is compatible with Laboratory Information Management Systems (LIMS).

NIMBUS Select

The NIMBUS Select automates sample handling for up to 96 size selections or 768 fragment analyses. Lower sample throughputs can still be processed cost-effectively as the RFID readers can identify previously used gel cassettes to enable unused channels to be used for new samples. The instrument comes with a 96-channel liquid handling manifold or a 384 manifold for laboratories looking to increase their throughput for fragment analyses.

Yourgene Health | NIMBUS Select with Ranger® Technology
Yourgene Health | NIMBUS Select with Ranger® Technology

The NIMBUS Select is a versatile 3-in-1 workstation, combining automated size selection, fragment analysis, and liquid handling in one. This automated instrument improves efficiency and reduces hands on-time, while increasing throughput compared to manual methods.

Yourgene offer a wide range of size selection and analytics cassettes with different size reference markers to meet the requirements of your application. Please contact us for help and advice on selecting the right consumables.

Size Selection Applications

Parameter
Specification
Additional Information
Allowable Size Range
0 bp - 20 kb
Different gel percentages available for optimum size-selection of targets within this range
Loading Capacity
≤ 1 kb: 500 ng - 2 μg
2 - 5 kb: 250 ng - 1.5 μg
10 kb: 500 ng - 1 μg
20kb: 250 - 500 ng
Exact loading capacity depends on the size range of interest and the gel percentage chosen
No. of Samples / Run
96
Compatible with CGI Cassettes
Run Time
1 - 4 hours
Depends on optimisation of reagent kit selection and required resolution
Intrinsic Recovery Efficiency
Average >70%
Dependent on run conditions, particularly the relationship between the target range and the extraction volume

Electropherogram Trace Generation

Parameter
Specification
Additional Information
Acceptable Size Range
50 bp - 20 kb
Different gel percentages permit analysis across different regions of this total range
Sizing Accuracy
5 - 20% of nominal size
Depends on the fragment size and the reagent kit selection. When working within the recommended size-range for each gel type, sizing accuracy is typically within 5%
No. of Samples / Run
192 - 384
Depends on resolution configuration required
Run Time
Typically 20 - 40 minutes
Depends on fragment size and reagent kit selection. Low voltage analysis of larger fragment (>20 kb) can take significantly longer depending on the settings
Intrinsic Recovery Efficiency
70 - 80%
Dependent on run conditions, particularly the relationship between the target range and the extraction volume

Plate-Based Quantification

Parameter
Specification
Additional Information
Lower Detection Limit
0.2 ng
When using the prescribed Pico-Green-based assay. Other fluorophores may provide increased sensitivity
Accuracy
+/- 15%
Depending on pipetting accuracy and the use of replicates, this number can be brought down

General

Parameter
Weight
Dimensions (W x D x H)
Physical Characteristics
101.2 kg
134 cm x 75 cm x 88 cm
Yourgene Health | the IONA® test

A Ranger® Technology Applications: Size Selection for NIPT, Oncology and Gene Synthesis Applications

In this edition of YourExpert, Yourgene Health interviewed Matthew Nesbitt, one of the developers of Ranger® Technology to discuss how its unique size selection function is helping our collaborators in life sciences and synthetic biology, across various clinical and research applications.

Download Paper
YEX014 Ranger® Technology Applications: Size Selection for NIPT, Oncology and Gene Synthesis Applications
YEX013 A Ranger® Technology Application Synthetic Biology and Gene Synthesis

A Ranger® Technology Application: Synthetic Biology and Gene Synthesis

In this edition of Your Expert, Yourgene Health interviewed Matthew Nesbitt, one of the developers of our breakthrough Ranger® Technology to discuss how its size selection function is revolutionising the approach to Gene Synthesis and how dozens of organisations are already benefitting from this function in the manufacture of their deliverables.

Download Paper

Videos

Introducing Ranger® Technology

Cloning Workflows Made Effective using Ranger® Technology and Automated Electrophoresis

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