Chemotherapy Resistance (DPYD)

 
Prev Next

Testing for the DPYD gene is recommended for patients planning to start systemic treatment with with 5-fluorouracil-based chemotherapies (as advised by the UK MHRA on 22 October 2020).

5-fluorouracil (5-FU) is the active chemotherapy agent in a range of commonly used drugs to treat a range of cancers e.g. Capecitabine, Tegafur. 5-FU is metabolized by the dihydropyrimidine dehydrogenase enzyme (DPD) which is encoded by the DPYD gene. Several variants within DPYD have been described that lead to reduced or abolished DPD activity. Patients with these variants are at an increased risk of severe adverse reaction to 5-FU or fatal 5-FU toxicity. Testing for DPD deficiency by DPYD genotyping allows more accurate prediction of 5-FU toxicity and adverse events. 

Our Service

Our DPYD assay is a simple genotyping test that can identify patients with DPD deficiency, allowing an alternative dosage to be offered to ensure that the treatment is safe for the patient before they undergo their treatment. 

Allelic Variant Detected

*2A

rs3918290

*2A

rs3918290

*13

rs55886062

*13

rs55886062

N/A

rs67376798

N/A

rs67376798

HapB3

rs75017182, rs56276561, rs56038477

HapB3

rs75017182, rs56276561, rs56038477

Sample Type

Yourgene Health | the IONA® test | 99% detection rate

Whole Blood

Target turn around time

Yourgene Health | the IONA® test | 99% detection rate

5 calendar days or less from receipt of specimen

Features

Please see our Contact forms below:
If you are a current customer or distributor, please complete the 'Current Customer' contact form. 
If you are interested in Yourgene's products/services and would like to enquire, please complete the 'New Enquiry' contact form.

Current Customer Contact Form


New Enquiry Contact Form


For current customers and distributors seeking access to product information including IFU’s, Software Analysis Files, Safety Data Sheets and Supplementary Information please login here

If you require a login please email marketing@yourgenehealth.com

If you have a question, need further information, or are interested in using our oncology services, we're here to help.