Yourgene Health uses Ranger® Technology in our next generation size selection instruments to deliver dynamic target enrichment of DNA. Core automated size selection functionality is complemented by the ability to perform fragment length analysis and fluorescence assays for next-generation sequencing (NGS) quality control applications. Ranger® Technology has so far been deployed to power multiple solutions across our instrumentation portfolio, with applications from liquid biopsy to non-invasive prenatal testing (NIPT) and beyond.
Ranger® Technology offers industry-leading scalability and precision for the size selection process, ensuring maximal enrichment, every time. Providing clinical and research laboratories with true walk away time, reducing workflow costs and improving yields.
Ranger® Technology offers a fast, effective and efficient automated solution for separating DNA molecules based on their size and electrical charge; it uses a patent-protected, machine-vision algorithms to interpret the gel electrophoresis process in real time. The high precision imaging feeds data into the algorithms which cleverly interpret the DNA separation process. The voltage is modulated per channel to control migration of DNA which ensures recovery yields are consistently over 70%. Extraction volumes can be kept to under 35 ul volumes to ensure a high concentration of DNA for downstream processing.
Combined with our dual reference size markers, which can be selected in line with the target of interest, ensures Ranger® Technology achieves a repeatable, high precision of 97%. In terms of recovery, we have high intrinsic recovery and resulting yields, which can result in higher enrichment of the DNA fragments of interest, and also achieve reduced noise in subsequent sequencing data.
As well as size selection Ranger® Technology also offers the ability to perform fragment length analysis and sample quantification with fluorescence-based assays. This results in time and reagent savings, allowing for accurate DNA quantification that can be integrated with automated workflows, giving better quality control of your samples.
Yourgene Health offer a range of state-of-the-art DNA sample preparation platforms that are powered by Ranger® Technology: NIMBUS Select, LightBench®, Yourgene ® QS250 and LightBench® Detect.
Ranger® Technology Solutions
LightBench®
powered by Ranger® Technology
The LightBench® is Yourgene's cornerstone sample preparation solution used in laboratories in research DNA sequencing communities.
Yourgene® QS250
powered by Ranger® Technology
The Yourgene® QS250 is available exclusively for clinical use in Yourgene Health’s NIPT workflows: IONA® Nx NIPT workflow and Sage™ 32 NIPT Workflow.
LightBench® Detect
powered by Ranger® Technology
The LightBench® Detect is designed specifically for clinical liquid biopsy applications, and leverages patent-pending technology to enable greater flexibility in blood tube collection choice.
NIMBUS Select
powered by Ranger® Technology
The NIMBUS Select, is the solution of choice for our partners with higher throughput requirements.
To complement our instruments, we have developed a range of consumables and reagents which have been optimized for use on these platforms. Please contact a member of our sales team to find out more.
Ranger® Technology can be utilised to improve workflows and performance in applications including NIPT, oncology, infectious disease testing and gene synthesis.
