The Sage™ Prenatal Screen is a simple, fast process that can be run by any trained technician. The Sage™ 12 NIPT Workflow is ideal for low to medium volume sample throughput laboratories, enabling laboratories to build up volumes and then transition seamlessly onto the Sage™ 32 NIPT Workflow to meet the rising demand for testing.
The Sage™ 12 NIPT Workflow is a manual, low cost, flexible solution for core trisomy screening, which enables 12 samples to be run simultaneously. As demand rises this workflow is easily scalable to the Sage™ 32 NIPT Workflow which offers both manual and automated options, increasing flexibility, scalability and sequencing efficiencies.
The Sage™ 32 NIPT Workflow enables 32 samples to be processed in one sequencing chip and utilises the Yourgene® QS250, powered by Ranger® Technology. Ranger® Technology allows automated high-throughput target enrichment of cfDNA NGS library constructs prior to sequencing, enabling great improvements in fetal fraction enrichment.
In NIPT, Ranger® Technology next generation size selection and enrichment enables labs to get the results they are looking for first time, reducing failure rates and improving precision, enabling more pregnant mothers to receive a safe, fast and accurate screening result.
In addition to next generation size selection, the Yourgene® QS250 also allows fragment analysis and solution-based fluorescence quantification assays with a single piece of equipment, giving greater cost efficiencies for the laboratory.
Both Sage™ Workflows run on the Ion Torrent sequencing system from Thermo Fisher Scientific.