Thrombosis Risk Panel

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The Yourgene® Thrombosis Risk Panel assay detects the four most relevant genetic mutations that are implicated with an increased risk of developing venous thromboembolism, enabling treatment to be offered.

Yourgene Thrombosis Risk Panel Kit

Thrombosis Risk Panel

Venous thromboembolism (VTE) occurs in 1-2 individuals per 1000. There are approximately 10 million cases worldwide, with between 100,000 and 300,000 VTE related deaths in the US, and 544,000 in Europe each year. This is a major health economic burden. There are many factors that increase the risk of thrombophilia such as surgery, pregnancy, the use of oral contraceptives and prolonged immobilisation (economy class syndrome).

Genetic factors also contribute to an individual’s risk of VTE. Factor V Leiden is the most common inherited form of thrombophilia, occurring in 3.8% of the general US and European population in a heterozygous state. Heterozygous individuals are 7-fold more likely to develop a VTE, while homozygous individuals have an 80-fold increased risk.

Prothrombin thrombophilia is the second most common form and occurs in approximately 1 in 50 people in Caucasian US and European populations. Mutations in MTHFR are associated with elevated homocysteine levels, an increased risk of blood clots, pregnancy loss or neural tube defects in offspring.

The Yourgene® Thrombosis Risk Panel uses fluorescent ARMS (Amplification Refractory Mutation System) allele specific amplification technology, which detects point mutations, insertions or deletions in DNA.

The Yourgene® Thrombosis Risk Panel assay is available as a CE-marked in vitro diagnostic product (IVD) product.

See our Product Menu for further information.

Yourgene® Thrombosis Risk Panel previously known as Elucigene® TRP-Fplus. 

The Yourgene® Thrombosis Risk Panel assay is easy to set up and involves minimal hands-on time. DNA extracted from whole blood is amplified using fluorescent ARMS and analysed quantitatively on a capillary electrophoresis genetic analyser. Results review and interpretation is simple with no data transfer required.

Test Features

Yourgene Health | the IONA® test | 99% detection rate

One PCR

    • Simple set up – one tube per sample
    • Rapid – minimum hands on time, just add DNA
    • One step protocol – DNA extraction to PCR
    • Reduced risk of sample mix-up
    • Efficient – fewer consumables, reduced cost
    Yourgene Health | the IONA® test | 99% detection rate

    One Analysis

      • Validated for use on the ABI 3130 and 3500 Genetic Analysers
      • Highly informative – multiplexed 5 dye chemistry
      • No post-PCR manipulation
      • One capillary per sample
      • Cost effective – less instrument consumables
      Yourgene Health | the IONA® test | 99% detection rate

      One Report

        • GeneMarker™ and GeneMapper® software applications
        • Simple data review and analysis
        • Easy to use intuitive software
        • Informative single page report
        • No data transfer required

        100% specificity and sensitivity

        Yourgene Health | Our Products | Assays and Applications | Thrombosis Risk Panel
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